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Keep an eye on Closely (1)pentobarbital will enhance the level or result of clopidogrel by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will minimize the level or effect of guanfacine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Carefully. Robust or moderate CYP3A4 inducers substantially de